Resolved: Normal Glomeruli Filter Nephrotic Levels of Albumin
نویسندگان
چکیده
منابع مشابه
Resolved: normal glomeruli filter nephrotic levels of albumin.
The glomerular filtration barrier has long been thought largely impermeable to albumin. Startling new data suggest it may not be especially important in this process. Much of the argument hinges on whether charge selectivity really exists, how feasible it is for enormous quantities of albumin to instead be reclaimed by the proximal tubule, and the technical merits of previous experiments. Three...
متن کاملThe normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.
The origin of albuminuria remains controversial owing to difficulties in quantifying the actual amount of albumin filtered by the kidney. Here we use fluorescently labeled albumin, together with the powerful technique of intravital 2-photon microscopy to show that renal albumin filtration in non-proteinuric rats is approximately 50 times greater than previously measured and is followed by rapid...
متن کاملMicropuncture studies of proximal tubule albumin concentrations in normal and nephrotic rats.
The concentration of serum albumin in proximal tubule fluid of normal rats and animals with aminonucleoside nephrosis was studied using renal micropuncture techniques. Albumin was quantitated by an ultramicrodisc electrophoresis method capable of measuring 3 chi 10(-11) g of albumin, in 10 nl volumes. With this sensitivity, only small samples of tubule fluid were required for analysis. Collecti...
متن کاملParietal podocytes in normal human glomeruli.
Although parietal podocytes along the Bowman's capsule have been described by electron microscopy in the normal human kidney, their molecular composition remains unknown. Ten human normal kidneys that were removed for cancer were assessed for the presence and the extent of parietal podocytes along the Bowman's capsule. The expression of podocyte-specific proteins (podocalyxin, glomerular epithe...
متن کاملDiseased renal glomeruli are getting soft. Focus on "Biophysical properties of normal and diseased renal glomeruli".
TISSUES AND CELLS are characterized by mechanical properties that are variously described as elasticity, deformability, or stiffness, which are critical components in determining their normal structure and function (reviewed in Ref. 25). However, biologists and physicians are not used to thinking of mechanical signals as having a primary role equivalent to biochemical signals in normal biology ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2008
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007090997